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Using patient-derived iPSC models, the PhD study identified several gene and protein expressional changes associated with clinical manifestation and increased risk to develop schizophrenia.
“Coronary artery disease has, for a long time, been mainly treated with cholesterol-lowering drugs, but there is a need for other types of treatments as well. For example, new drugs could target pathogenic changes taking place in the arterial wall,” Professor Minna Kaikkonen-Määttä says.
Hexanucleotide repeat expansion in the C9orf72 gene leads to structural and functional changes in synapses that connect neurons, a new study shows.
The awards ceremony was held on 16 December at Kuopio Campus.
The University of Eastern Finland participates in six of the funded FIRI consortia, and funding for the development of infrastructures was granted to all faculties of the university.
Novel induced pluripotent stem cell (iPSC) technologies were established and utilized to study human microglia and astrocytes in order to elucidate the early inflammatory pathology in Alzheimer’s disease.
New techniques make it possible to acquire a comprehensive 3D morphometry of white matter ultrastructures,
The research collaboration agreement is in the field of gene and cell therapy, and it will strengthen the development and production of new gene therapy vectors.
Diffusion tensor imaging detected status epilepticus-induced changes rather early in the rat hippocampus, and the changes were associated with myelinated axons and astrocyte processes in the tissue.